Endocrine Abstracts

Estrogen signaling is mediated by two isoforms of the soluble estrogen receptor (ER), ERα and ERβ. In general, ERα and ERβ appear to have distinct, specific actions, sometimes of antagonistic nature (yin/yang). ERβ is widely distributed and studies on mice with deleted ERβ show phenotypic alterations in many tissues, indicating that ERβ has essential roles in several physiological contexts. In the CNS, ERβ is essential for development of...

We have previously shown that in pancreatic ductal epithelial cells, the expression of the water channel aquaporin-1 is under the control of the oxysterol receptor liver X receptor β. The aim of the present study was to investigate water balance in mice lacking each LXR isoform.Given free access to water, LXRβ−/− mice demonstrated an abnormal daily excretion of highly diluted urine, polyuria, with increased water intake compared to ...

The oestrogen receptor (ER) is a ligand-inducible transcription factor that controls expression of a number of genes in a wide variety of tissues. Binding of the natural hormone, oestradiol, triggers dimerisation and nuclear location of the receptor and assembly of a functional transcriptional complex through recruitment of various coactivators.In this talk, I will discuss how knowledge of the structure of the receptor has had a major impact on our under...

Introduction: Heart failure is characterised by an up-regulation of neurohoromones, and brain natriuretic peptide (BNP) and atrial natriuretic peptide (ANP) are well-established diagnostic biomarkers with substancial prognostic value. Adrenomedullin is a vasoactive peptide and a potential biomarker of vascular injury in patients with cardiovascular disease (CVD) The aims of the present study were to investigate whether mid-regional pro adrenomedullin (MR-proADM) is predictive ...